Analysis of the preventive and therapeutic effects of Taohe Chengqi decoction on a rat model of hepatic encephalopathy
10.3969.j.issn.1671-7856.2016.10.004
- VernacularTitle:桃核承气汤对大鼠肝性脑病模型干预治疗的分析
- Author:
Xiaojuan LI
;
Yun ZHU
;
Lifu WANG
;
Ning DU
;
Yongqiang SUN
;
Xueai SONG
;
Jing JING
;
Liping WANG
;
Fan ZHANG
;
Simiao YU
;
Ruilin WANG
;
Ruisheng LI
- Publication Type:Journal Article
- Keywords:
Taohe Chengqi decoction;
Hepatic encephalopathy;
Thioacetamide;
Rat
- From:
Chinese Journal of Comparative Medicine
2016;26(10):14-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the preventive and therapeutic effects of a traditional Chinese medicine Taohe Chengqi decoction on a rat models of hepatic encephalopathy ( HE) induced by thioacetamide ( TAA) .Methods The rat model of HE was established by intraperitoneal injection of TAA,and the effects of Taohe Chengqi decoction were observed by neurobehavioral changes,neurological test,blood ammonia,serum biochemical indexes,and liver and brain pathological examination.Results The rat model of hepatic encephalopathy was successfully established.Low, medium and high dose Taohe Chengqi decoction markedly improved neuro-reflexes and liver and brain pathological damages, and significantly decreased the HE staging and serum biochemical indexes, and the results of high dose group was the best, similar to that of positive drug-treatment group.Conclusions Taohe Chengqi decoction exhibits promising preventive and therapeutic effects on the rat model of TAA-induced hepatic encephalopathy, and these results provide substantial experimetal evidence for its clinical application.
