Detection of biomarkers and its clinical signiifcance in the inlfammatory bowel disease in Children

VernacularTitle:儿童炎症性肠病生物学标志物检测及其临床意义
Author: Hui YANG ; Yu JIN ; Mei LI ; Lihua HAO
Publication Type:Journal Article
Keywords: inlfammatory bowel disease; biological markers; child
From: Journal of Clinical Pediatrics 2016;34(10):721-725
CountryChina
Language:Chinese
Abstract: Objective To investigate the biological markers and their clinical significance in diagnosis and differential diagnosis of inlfammatory bowel disease (IBD) in children.Methods The study had 22 cases of IBD including 6 cases of ulcerative colitis (UC) and 16 cases of Crohn’s Disease (CD). Twenty-four children without IBD were selected as controls. The serum perinuclear anti-neutrophil cytoplasmic antibody (pNACA) was measured by indirect immune lfuorescence method. The serum anti-saccharomyces cerevisiae antibody (ASCA) IgG and IgA, anti-B mannose glycoside antibody (AMCA) IgG, anti-B glycoside sugar shell antibody (ACCA) IgA, Anti-bacterial lfagellin antibody (Anti-cBir1) IgG, and the fecal calprotectin (FC) were determined by Enzyme linked immunosorbent assay (ELISA). Results The positive rate of serum pANCA was 100% in 6 cases of UC while it was negative in CD cases and control, and there was significant difference among three groups (P