NR5A1 gene mutation in child with 46, XY disorders of sex development：a case report and literature review
10.3969/j.issn.1000-3606.2016.10.014
- VernacularTitle:46，XY性发育障碍儿童NR5A1基因突变1例报告及文献复习
- Author:
Juan LI
;
Jian WANG
;
Yongnian SHEN
;
Xiumin WANG
;
Xiaodong HUANG
;
Yu DING
;
Yao CHEN
- Publication Type:Journal Article
- Keywords:
46,XY DSD;
NR5A1 gene;
mutation;
child
- From:
Journal of Clinical Pediatrics
2016;34(10):771-774
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical features and molecular diagnosis of 46, XY disorder of sex development (46, XY DSD).Methods The clinic data of one child with 46, XY DSD raised as female were retrospectively analyzed, and related literatures were reviewed.Results The 11.5-year-old child raised as female visited clinic due to, “accidently found clitoral hypertrophy for half month”. Preliminary series of laboratory examinations supported the diagnosis of 46, XY DSD, high gonadal hormone dysplasia. DNA sequencing of the whole genome exon group showed a heterozygous mutation of c.937C>T, p.Arg313Cys inNR5A1 gene. No abnormality was detected in her father, while her mother was a heterozygous mutation carrier. Conclusions 46, XY DSD can be diagnosed by the whole genome exon gene sequencing.
