The biological advance in acute lymphoblastic leukemia of t (4;11) in infants
10.3969/j.issn.1000-3606.2016.10.018
- VernacularTitle:t（4;11）婴儿急性淋巴细胞白血病生物学研究进展
- Author:
Huimin ZENG
;
Yingxi ZUO
;
Leping ZHANG
- Publication Type:Journal Article
- Keywords:
leukemia;
gene rearrangement of MLL;
MLL-AF4;
infant
- From:
Journal of Clinical Pediatrics
2016;34(10):787-791
- CountryChina
- Language:Chinese
-
Abstract:
Infant acute lymphoblastic leukemia B (B-ALL) accounts for 10% of childhood ALL. Eighty percent of infant B-ALL was caused byMLL gene rearrangement (MLL-r). The overall survival rate of ALL was less than 35% in infants with MLL-r. Among infant ALL with MLL-r, infants with positivefusion geneMLL-AF4 (MA4) formed by chromosome t (4;11) had even poor prognosis. Studies in monozygotic twins and archived blood spot at birth had veriifed that fusion gene MA4 originated from antenatal. Whole genome sequencing found that t (4;11) alone might be sufifcient to spawn leukemia. This paper is going to summarize the advances in biological characteristics such as clinical features, cellular origin, genomics and disease models of normalMLL gene and infant B-ALL withMA4.
