Correlation Analysis of HCV-RNA,HCV-Ab and HCV-cAg
10.3969/j.issn.1671-7414.2016.05.034
- VernacularTitle:HCV-RNA与 HCV-Ab，HCV-cAg相关性分析研究
- Author:
Ya LI
;
Yun ZHANG
;
Hai HUANG
;
Di ZHANG
;
Mingquan SU
;
Xuchang GUO
- Publication Type:Journal Article
- Keywords:
hepatitis C virus;
HCV-RNA;
HCV-cAg;
HCV-Ab
- From:
Journal of Modern Laboratory Medicine
2016;31(5):120-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of HCV-RNA with detection indexes HCV-Ab and HCV-cAg in its clini-cal application effect among patients with hepatitis C.Methods HCV-cAg and HCV-Ab in 140 cases of HCV-RNA were detected by enzyme linked immunosorbent assay in cases of PCR,which were detected by real-time fluorescence quantitative PCR.Results 127 cases in 140 cases of HCV-RNA positive serum were HCV-cAg positive,in line with the rate of 90.71%,and the cases of 110 HCV-Ab positive,in line with the rate of 78.57%.The positive detection rate of HCV-cAg with different HCV-RNA concentration was increased with the increase of HCV virus content,and the serum of different HCV-RNA concentration had no significant changes in HCV-Ab detection results.Conclusion The detection results of HCV-cAg had a high coincidence rate with HCV-RNA.Therefore detection of HCV-cAg can be as a complementary detec-tion of HCV-Ab,as the window period of HCV infection and infection in immunocompromised persons screening provides a simple,inexpensive method.At the same time it provides rapid screening for HCV infection provide diagnostic basis for those basic medical units who do not have the conditions for detection of HCV-RNA.
