Association of serum PGE-2 and VEGF levels and the expression of VEGF in gastric can-cer tissue and clinicopathological features of gastric carcinoma patients with hyperlip-idemia
10.3969/j.issn.1000-8179.2016.19.843
- VernacularTitle:合并高脂血症的胃癌患者PGE2 VEGF表达水平和临床病理特征的相关研究
- Author:
Ao ZHANG
;
Jia LIU
;
Fei HUANG
;
Yang ZHOU
;
Weidong LI
;
Weihua FU
;
Tong LIU
- Publication Type:Journal Article
- Keywords:
gastric carcinoma;
hyperlipidemia;
prostaglandin E2;
vascular endothelial growth factor;
clinical pathological features
- From:
Chinese Journal of Clinical Oncology
2016;43(19):845-848
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to compare the difference in the expression levels of prostaglandin E2 (PGE2), vascular endotheli-al growth factor (VEGF), and the clinicopathological features among gastric carcinoma patients with and without hyperlipidemia and to assess whether hyperlipidemia promotes gastric carcinoma progression. Methods:We analyzed the PGE2 and VEGF serum levels and the VEGF expression in gastric carcinoma tissues in 102 gastric carcinoma patients. The PGE2 and VEGF serum levels were detected by enzyme-linked immunosorbent assay, and the VEGF expression in gastric carcinoma tissues was detected by SABC immunohistochemi-cal staining. Results:Among the 102 gastric carcinoma patients, 49 patients had hyperlipidemia, and 53 did not have the condition. The PGE2 and VEGF expressions in the serum and the VEGF expression in gastric carcinoma tissues were higher in hyperlipidemic pa-tients than in those without hyperlipidemia (P<0.05). The degrees of differentiation, depths of invasion, lymph node metastasis, and TNM staging in the two groups also showed statistical differences (P<0.05). Conclusion:Hyperlipidemia possibly contributes to the pro-gression of gastric carcinoma by upregulating the PGE2 and VEGF expressions.
