Expression and clinical significance of CXCL14 and EGFR in human gastric cancer
10.3969/j.issn.1000-8179.2016.19.786
- VernacularTitle:CXCL14和EGFR在胃癌组织中的表达及其临床意义
- Author:
Xue YANG
;
Tao HE
;
Lifang SHI
;
Shufang ZHENG
- Publication Type:Journal Article
- Keywords:
gastric cancer;
CXCL14;
EGFR;
immunohistochemistry
- From:
Chinese Journal of Clinical Oncology
2016;43(19):860-864
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of C-X-C chemokine ligand-14 (CXCL14) and epidermal growth factor receptor (EG-FR) in human gastric cancer and to analyze the relationship of CXCL14 with clinicopathological features. Methods:The expression of CXCL14 and EGFR was detected by Immunohistochemical SP method in 121 cases of gastric cancer tissue, 62 cases of the adjacent non-tumor gastric mucosa, and 60 cases of allogeneic non-tumor gastric mucosa. Results:The positive rates of CXCL14 and EGFR expres-sion were 80.17%and 48.76%in gastric cancer, respectively, and both were significantly higher in the adjacent non-tumor gastric mu-cosa and allogeneic non-tumor gastric mucosa. The differences were significant (P<0.01). Overexpression of CXCL14 was closely corre-lated with the depth of cancer invasion, differentiation, and clinical stage, and the differences were significant (P<0.05). Overexpres-sion of EGFR was correlated with cancer differentiation, lymph node metastasis, and clinical stage. The differences were significant (P<0.05). Based on the Spearman correlation analysis, the expression of CXCL14 and EGFR in gastric cancer was positively correlated (rs=0.195, P<0.05). Conclusion:Abnormal CXCL14 expression in gastric cancer may be associated with the occurrence and development of gastric cancer. CXCL14 expression is positively correlated with EGFR expression, suggesting that the two have a synergistic effect in gas-tric cancer development.
