The research development of Chimeric Antigen Receptor T-cells in hematological malignancies
10.11904/j.issn.1002-3070.2016.05.018
- VernacularTitle:CAR －T 细胞治疗在血液系统恶性肿瘤中的研究进展
- Author:
Xiuli SANG
;
Ce SHI
;
Jin ZHOU
- Publication Type:Journal Article
- Keywords:
Chimeric antigen receptor T -cells;
Hematological;
Malignancy
- From:
Practical Oncology Journal
2016;30(5):473-476
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,chimeric antigen receptor T -cells(CAR-T cells)therapy becomes the new rapid development of adoptive tumor immunotherapy .Its main characteristic is to identify specific T cell receptor of tumor antigen by genetic engineering modification and give its targeting ,killing and persistent treatment .The CAR-T was mentioned for the first time in 1989,and has developed to the fourth generation .CD19-CAR-T treatment technique shows activity in phase I clinical trials of multiple research centers .CAR-T therapy is ex-pected as a new way to cure relapse/refractory hematological malignancies .
