Research progress of SALL4 gene in malignant tumor disease
10.11904/j.issn.1002-3070.2016.05.019
- VernacularTitle:SALL4基因在人恶性肿瘤中的研究进展
- Author:
Jue WANG
;
Huijie ZHANG
- Publication Type:Journal Article
- Keywords:
Proto-oncogene;
SALL4;
Tumor
- From:
Practical Oncology Journal
2016;30(5):477-480
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumor is a serious threat to human health and its pathogenesis is complex , which caused by interaction of a variety of carcinogenic factors in the human body .SALL4 gene is a kind of newly dis-covered gene and it plays an important role in function of embryonic stem cell due to its protein transcription fac -tor with C2H2 zinc finger domain.Studies found that this gene mutation often results in occurrence of malignant tumor.This paper will summarize the molecular mechanism of SALL 4 in the occurrence and development of malig-nant tumor and its diagnosis and treatment on malignant tumor .
