Optimal atropine treatment for severe acute organophosphate poisoning

VernacularTitle:重症急性有机磷中毒的阿托品优化治疗
Author: Xuexi HAO ; Mingju SHAO
Publication Type:Journal Article
Keywords: Acute organophosphate pesticide poisoning; Atropine; Optimal treatment
From: Chinese Critical Care Medicine 2016;28(10):954-956
CountryChina
Language:Chinese
Abstract: Atropine has been an effective drug antagonizing M-like symptoms induced by severe acute organophosphate pesticide poisoning (AOPP), which could relieve bronchospasm, inhibit glandular secretion, and prevent pulmonary edema. In the rescue of severe AOPP, a hypo-dose of atropine is difficult to effectively block the effect of acetylcholine, and overdose plays great risk of atropine poisoning. When the patient's condition improves, the rebound often occurs in the process of withdrawal. Medical workers at home and abroad have conducted a lot of study to explore the personalized judgment of atropinization and optimal treatment of atropine for severe AOPP, including the initial bolus of atropine,the sustained infusion for the treatment of pulmonary edema, the maintenance dose, extenuation and withdrawal of atropine for the prevention of its overdose. Related researches in recent years were reviewed to provide the clinical reference.