Association of EGFR mutation with histologic subtypes in lung adenocarcinoma
10.3969/j.issn.1673-4130.2016.20.007
- VernacularTitle:表皮生长因子受体基因突变与肺腺癌亚型关系的研究
- Author:
Xin LI
;
Yunjian XU
;
Chenghemei ZHANG
- Publication Type:Journal Article
- Keywords:
lung adenocarcinoma;
epidermal growth factor receptor;
gene mutation;
histologic subtype
- From:
International Journal of Laboratory Medicine
2016;37(20):2820-2822
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the association of epidermal growth factor receptor (EGFR) mutation with histologic subtypes in lung adenocarcinoma .Methods Lung cancer tissues were collected from 3 028 cases of patients with non‐small cell lung cancer , DNA was extracted respectively ,and EGFR gene exons 18 ,19 ,20 and 2l mutations were dectected by ARMS‐PCR amplification . The association of EGFR mutation with histologic subtypes in lung adenocarcinoma was analyzed .Results The mutation rate of EGFR detection was 39 .7% ,most were exon 19 del and exon 21 L858R (proportion 89 .8% );according to the new classification , EGFR gene mutation in infiltrating lesions with micro infiltrating adenocarcinoma and infiltrating adenocarcinoma were different (P<0 .05) .EGFR mutation rates were higher in moderately differentiated lung adenocarcinoma ,degree of differentiation of EGFR mutation rates were statistically different(P<0 .05) .Conclusion The new classification showes a correlation with molecular diag‐nosis ,different subtypes of EGFR mutation rate is different .There is a certain correlation between EGFR gene mutation and the de‐gree of differentiation in adenocarcinoma .
