The relationship of tumor marker and CD4+T cells before and after radiotherapy on patients
10.3969/j.issn.1673-4130.2016.20.010
- VernacularTitle:CD4＋T 细胞与放疗前后肿瘤标志物变化
- Author:
Jiang ZHU
;
Jinxiang HE
;
Jinchun HE
- Publication Type:Journal Article
- Keywords:
breast cancer;
CD4+ T cell;
CEA;
AFP;
CA125;
CA15-3
- From:
International Journal of Laboratory Medicine
2016;37(20):2828-2830
- CountryChina
- Language:Chinese
-
Abstract:
Objective The study is aimed to research into the effect of CD4+ T cells on patients with severe advanced breast cancer under radiotherapy that cannot be treated with surgery ,by observing the variation of CEA ,AFP ,CA125 and CA15‐3 before and after the radiotherapy applied .Methods We identified the CEA ,AFP ,CA125 and CA15‐3 densities in blood serum for a group of 38 patients with advanced breast cancer and a group of 30 normal people with chemiluminescence immune assay ,and we deter‐mined the CD3+ ,CD4+ ,CD8+ T percentage in peripheral blood and the ratio of CD4+ /CD8+ with flow cytometry .Results The group with normal CD4+ T percentage went through a decreased in CEA ,AFP ,CA125 ,CA15‐3 densities after the radiotherapy ,and the variation was significant(P<0 .05) .The group of people with abnormal CD4+ T percentage go through CEA ,CA15‐3 densities decrease after the radiotherapy ,and the variation was statistically significant(P< 0 .05) .Conclusion For those with advanced breast cancer and cannot be treated with surgery ,the influence of radiotherapy on CEA ,AFP ,CA125 ,CA15‐3 densities is significant in the group of patients with CD4+ T percentage ,adn has better therapeutic effect .
