Efficacy Observation of Candesartan Combined with Sulodexide Soft Capsules in the Treatment of Persistent Proteinuria of Diabetic Nephropathy
10.6039/j.issn.1001-0408.2015.29.34
- VernacularTitle:坎地沙坦联合舒洛地特软胶囊治疗糖尿病肾病持续蛋白尿的疗效观察
- Author:
Hongzhen PAN
- Publication Type:Journal Article
- Keywords:
Candesartan;
Sulodexide soft capsules;
Diabetic nephropathy;
Proteinuria period
- From:
China Pharmacy
2015;(29):4130-4132
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe therapeutic efficacy of candesartan combined with Sulodexide soft capsules in the treatment of persistent proteinuria of diabetic nephropathy. METHODS:180 patients with persistent proteinuria of diabetic ne-phropathy were randomly divided into control group and trial group,with 90 cases in each group. Control group was given can-desartan,8 mg/time,once a day;trial group was additionally given Sulodexide soft capsules on the basis of control group,250 LSU/time,twice a day. The indexes levels of both groups were compared before and after treatment,including systolic blood pressure(SBP),diastolic blood pressure(DBP),serum creatinine(Scr),blood urea nitrogen(BUN),urinary albumin excre-tion rate (UAER),24 hour urinary albumin (24hU-Alb) and urinary 2-microglobulin (β2-MG),α1 microglobulin (α1-MG), urine N-acetyl-β-D glucoside enzyme(NAG)and serum cystatin C(Cys-C). RESULTS:After treatment,there was no statisti-cal significance in the levels of SBP,DBP,Scr,BUN and UAER between 2 groups(P>0.05);24hU-Alb level of observation group was significantly betRter than that of control group,with statistical significance (P<0.05);after treatment,β2-MG,α1-MG,NAG and Cys-C of 2 groups were all improved significantly,and the trial group was more significant then the control group,with statistical significance (P<0.05). CONCLUSIONS:Candesartan combined with Sulodexide soft capsules in the treatment of persistent proteinuria of diabetic nephropathy can effectively improve renal function and reduce urinary microalbu-min.
