Efficacy Observation of Dexmedetomidine for Cerebral Protection in Brain Aneurysm Surgery
10.6039/j.issn.1001-0408.2015.29.36
- VernacularTitle:右美托咪定用于脑血管瘤术中脑保护的疗效观察
- Author:
Fei XIA
;
Jincheng LI
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Brain aneurysm;
S100βprotein;
Neuron specific enolase;
Cerebral protection
- From:
China Pharmacy
2015;(29):4135-4137
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the cerebral protective effects of dexmedetomidine in brain aneurysm surgery. METH-ODS:48 patients with intracranial aneurysm were randomly divided into observation group and control group,with 24 cases in each group. Observation group was given dexmedetomidine 1 μg/kg,pump time 10 min,at rate of 0.5 μg/kg;control group re-ceived constant volume of normal saline. Hemodynamic changes,the levels of S100β protein and neuron specific enolase (NSE) were compared between 2 groups. RESULTS:The heart rate and mean arterial blood pressure were more stable in the observation group after medication,with statistical significance(P<0.05). The serum level of S100β protein at the end of operation(T5),6 h after operation(T6),12 h after operation(T7),24 h after operation(T8)were(1.52±0.35)μg/L,(1.69±0.33)μg/L,(1.72±0.42)μg/L,(2.08±0.57)μg/L;the serum level of NSE were(10.9±1.2)ng/L,(13.5±1.5)ng/L,(16.8±2.8)ng/L and(19.7±4.3)ng/L in observation group;those were all lower than in control group,with statistical significance(P<0.05). CONCLUSIONS:Dexme-detomidine for cerebral aneurysm operation is helpful for hemodynamics stability,and result in lower S100β protein and NSE. So it is important for cerebral protection.
