Clinical Observation of Breviscapine Combined with Double Shock in the Treatment of Lupus Encephalopa-thy
10.6039/j.issn.1001-0408.2015.27.13
- VernacularTitle:灯盏花素联合双冲击疗法治疗狼疮脑病的临床观察
- Author:
Lijun YAN
;
Zhequn SHI
;
Ge ZHANG
;
Ping WU
;
Zhiguo WANG
;
Jing LIU
;
Jing FENG
- Publication Type:Journal Article
- Keywords:
Breviscapine;
Double shock therapy;
Lupus encephalopathy;
Efficacy;
Safety
- From:
China Pharmacy
2015;(27):3779-3781
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of breviscapine combined with double shock in the treatment of lu-pus encephalopathy. METHODS:70 patients with lupus encephalopathy were randomly divided into control group and observation group. Control group was treated with Methylprednisolone sodium succinate for injection 500 mg for continuous 3 d,iv,once a day,Cyclophosphamide for injection 1.0 g in the 4th day,iv,and Methylprednisolone sodium succinate for injection 80 mg was used for maintaining treatment in the 5th day for continuous 15 d,once a day. Observation group was treated with Breviscapine for injection 50 mg for continuous 20 d based on the treatment of control group,iv,once a day. The SLE activity(SLEDAI) score, IL-1β,IL-6,IL-8 and IFN-γ were observed,cases of neurological and psychological symptoms,the fatality rate and incidence of adverse reactions were recorded. RESULTS:After treatment,the SLEDAI,IL-1β,IL-6,IL-8 and IFN-γ in 2 groups were signifi-cantly lower than before,and observation group was lower than control group(P<0.05);the cases of neurological symptoms(ex-cept for aseptic meningitis) and psychological symptoms (except for auditory hallucinations) were significantly less than control group(P<0.05). There was no significant difference in the mortality rate and incidence of adverse reactions(P>0.05). CONCLU-SIONS:Breviscapine combined with double shock has good efficacy and safety in the treatment of lupus encephalopathy,it can re-duce the SLEDAI score,improve neurological and psychological symptoms.
