Systematic Review of the Efficacy of Agomelatine in the Treatment of Depression in Acute Phase
10.6039/j.issn.1001-0408.2015.27.27
- VernacularTitle:阿戈美拉汀治疗抑郁症急性期疗效的系统评价
- Author:
Lin SONG
;
Yao LIU
;
Ling WANG
;
Xuehua JIANG
;
Rong GU
;
Yuntao JIA
- Publication Type:Journal Article
- Keywords:
Agomelatine;
Depression;
Meta-analysis;
Randomized controlled trial;
Systematic review;
Efficacy
- From:
China Pharmacy
2015;(27):3819-3822
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically review the efficacy of agomelatine in the treatment of depression in acute phase, and provide evidence-based reference for the clinical treatment. METHODS:Retrieved from Cochrane Library,Medline,EMBase, CJFD,VIP,CBM,Wanfang Database,WHO Clinical Trials Registry Platform and American Clinical Trials Registry Platform, the randomized controlled trials (RCT) about agomelatine versus placebo in the depression patients in acute phase. After quality evaluation and data extraction,Meta-analysis was conducted by using Rev Man 5.2 statistics software. RESULTS:A total of 7 RCT were included,involving 2 378 patients. Results of Meta-analysis showed the effective rate in agomelatine group was obviously bet-ter than placebo group [RR=1.43 ,95%CI(1.29 ,1.59),P<0.001] ,remission rate was obviously better than placebo group [RR=1.27 ,95%CI(1.03 ,1.57),P=0.02] ,and the endpoint score of depression scales was obviously lower than placebo group [MD=-2.92,95%CI(-3.65,-2.20),P<0.001],there was statistically significance. CONCLUSIONS:Agomelatine is effective in the treatment of depression patients in acute phase. However,due to the limit of methodological quality and sample size,it remains to be further verified with more rigorously designed and long-term follow-up of large-scale RCT.
