Effects of Rosiglitazone on Body Weight,FPG,FFA and Other Indicators in Diabetes Model Rabbit
10.6039/j.issn.1001-0408.2015.28.14
- VernacularTitle:罗格列酮对糖尿病模型兔体质量、FPG及FFA等指标的影响Δ
- Author:
Rixin ZHAN
;
Fang DONG
;
Lexiang LAI
;
Yilin ZHANG
;
Ming HUA
- Publication Type:Journal Article
- Keywords:
Rosiglitazone;
Rabbit;
Body weight;
Fasting glucose;
Free fatty acids;
ADR
- From:
China Pharmacy
2015;(28):3929-3931
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effects of rosiglitazone(RH)on body weight,FPG,FFA and other indicators in diabe-tes model rabbit. METHODS:18 rabbits were evenly randomized into control group,model group and dextran group. The latter 2 groups were given alloxan intravenously to induce diabetes model. 3 groups were given RH(0.5 mg/kg)intragastrically,and dex-tran group was additionally given dextran 40 glucose injection(5 ml/kg)intravenously,once a day,for consecutive 3 weeks. Body weight,serum level of FPG,FFA,AngⅡ and NO were determined before and after medication. RESULTS:Compared with be-fore medication,body weight of rabbits in control group were increased after medication,while the levels of FFA and AngⅡ were decreased;the levels of FPG and FFA were decreased in model group;body weight of rabbits were decreased in dextran group af-ter medication,with statistical significance (P<0.01 or P<0.05);other indicators had no statistically significant difference (P>0.05). The level of FFA in dextran group was higher than in model group after medication,with statistical significance(P<0.01). CONCLUSIONS:Rosiglitazone can lead to weight gain by a mechanism which reduce the level of FFA.
