Preparation of Borneol-puerarin Liposomes and Study on Its Brain-targeting
10.6039/j.issn.1001-0408.2015.28.25
- VernacularTitle:冰片-葛根素脂质体的制备及其脑靶向性研究Δ
- Author:
Weizhi LIU
;
Hankun HU
;
Ping LIU
;
Wei LIU
;
Yan ZHENG
- Publication Type:Journal Article
- Keywords:
Borneol;
Puerarin;
Liposome;
Brain distribution;
Preparation
- From:
China Pharmacy
2015;(28):3964-3966
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare borneol-puerarin liposomes,and to investigate its brain-targeting. METHODS:Film dis-persion ultrasonic method was used to prepare borneol-puerarin liposomes. The morphology of liposomes was observed by TEM;the particle size and Zeta potential were measured by laser particle size analyzer;the entrapment efficiency were measured by sepha-dex gel filtration method. Compared with Puerarin injection,brain-targeting of borneol-puerarin liposomes and puerarin liposomes via intravenous injection of mice tail was studied with relative intake rate and peak concentration ratio. RESULTS:Borneol-puerarin liposomes were spherical or quasi-circular;its mean particle size,polydispersity index and Zeta potential were 226 nm,0.263 and-21.3 mV respectively. The entrapment efficiency were(65.32±2.13)%. Compared with Puerarin injection,relative intake rate of puerarin liposome and borneol-puerarin liposome were 1.68 and 2.58,and peak concentration ratio were 1.15 and 1.42. CONCLU-SIONS:Brain-targeted borneol-puerarin liposomes are prepared successfully.
