Significance of Tacrolimus Blood Concentration Monitoring to the Therapy of Membranous Nephropathy
10.6039/j.issn.1001-0408.2015.26.14
- VernacularTitle:他克莫司血药浓度监测在膜性肾病治疗中的意义
- Author:
Dongmei YE
;
Chaoqing WU
;
Qingrong SHEN
;
Xuefeng JIN
- Publication Type:Journal Article
- Keywords:
Tacrolimus;
Membranous nephropathy;
Blood concentrations;
Clinical efficacy
- From:
China Pharmacy
2015;(26):3649-3651
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the significance of tacrolimus blood concentration monitoring to the therapy of mem-branous nephropathy. METHODS:41 patients with membranous nephropathy received tacrolimus,and the blood concentration of ta-crolimus reached to steady state. The trough concentration of tacrolimus was determined by EMIT. The patients were followed up, and clinical therapeutic efficacies were recorded. The relationship of blood concentration of tacrolimus with clinical efficacy was evaluated by SPSS 16.0 software. RESULTS:The blood concentration of tacrolimus was(7.47±2.74)ng/ml in complete remission (CR)group,(5.72±1.19)ng/ml in partial response(PR)group,and(3.30±1.08)ng/ml in no response(NR)group,with total remission rate of 75.61%. The blood concentration of CR group was the highest,followed by PR group and NR group,there was statistical significance among 3 groups(P<0.05). CONCLUSIONS:The clinical efficacy of tacrolimus in the treatment of nephrot-ic syndrome is correlate to the blood concentration intimately. Trough concentration monitoring of tacrolimus has important signifi-cance to the treatment of membranous nephropathy.
