Comparison of Plasma Concentration of Norvancomycin by HPLC and Microbiological Method
10.6039/j.issn.1001-0408.2015.26.16
- VernacularTitle:HPLC法与微生物法测定人血浆中去甲万古霉素浓度的差异比较
- Author:
Kaili ZHANG
;
Cheng LI
;
Yuzhen LI
;
Chunzhi YANG
- Publication Type:Journal Article
- Keywords:
HPLC;
Microbiological method;
Norvancomycin;
Plasma concentration
- From:
China Pharmacy
2015;(26):3655-3657
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the differences of plasma concentration of norvancomycin by HPLC and microbiological method. METHODS:Microbiological method and HPLC were used to detect the plasma concentration of norvancomycin,and clinical test result of both techniques was retrospectively analyzed. RESULTS:There were no significant differences in the plasma concentra-tion of norvancomycin by microbiological method and HPLC(y=0.992 7x+0.155 8,r=0.997 6)(P>0.05). CONCLUSIONS:Both microbiological method and HPLC are more effective and reliable for the plasma concentration detection of norvancomycin. The hospi-tals can choose corresponding method according to their condition when determining plasma concentration of norvancomycin.
