Relationship between Carbapenems Dosage and the Resistance of Klebsiella pneumonia
10.6039/j.issn.1001-0408.2015.26.18
- VernacularTitle:我院碳青霉烯类药物使用量与肺炎克雷伯菌耐药相关性分析
- Author:
Fang WU
;
Zude LIU
;
Zhiying CHENG
- Publication Type:Journal Article
- Keywords:
Carbapenems;
Klebsiella pneumonia;
Drug resistance;
Bacterial culture;
Sensitivity test
- From:
China Pharmacy
2015;(26):3660-3662
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide reference for rational use of antibiotics in the clinic. METHODS:The study quarterly count the dosage of carbapenems,the department distribution of cultured K. pneumonia (271 strains) during Oct. 1st 2013-Sept. 30th 2014,and it’s resistant rates to carbapenems and then investigate the correlation of dosage of carbapenem and drug-resistance of K. pneumoniae. RESULTS:Carbapenem drugs are mainly used in these departments,such as neurosurgery department,ICU and the departments of transplantation and respiratory. Carbapenem-resistant K. pneumonia was also detected in these departments. More-over,with the usage of carbapenem increased by from 64.24% to 360.63%,and the resistant rates of K. pneumonia increased by nearly 10%. CONCLUSIONS:The resistance rates of K. pneumonia is positively related to the amount of carbapenem;the amount control of carbapenems can delay the generation of K. pneumonia.
