Influence of Intravitreal Injection of Ranibizumab on Visual Acuity and GAS6,SDF-1 and VEGF in Serum of Patients with Proliferative Diabetic Retinopathy Lesions
10.6039/j.issn.1001-0408.2015.26.32
- VernacularTitle:玻璃体腔注射雷珠单抗对增殖性糖尿病性视网膜病变患者视力及血清GAS6、SDF-1与VEGF的影响
- Author:
Xinfang ZHANG
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy;
Ranibizumab;
Vitreous cavity;
GAS6;
SDF-1;
VEGF;
Visual acuity
- From:
China Pharmacy
2015;(26):3700-3702
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of intravitreal injection of ranibizumab on visual acuity and GAS6,SDF-1 and VEGF levels in serum of patients with proliferative diabetic retinopathy lesions. METHODS:56 patients diagnosed as prolifera-tive diabetic retinopathy in our hospital during Mar. 2012 to Mar. 2014 were analyzed retrospectively and divided into simple lateral eyes group(29 cases)and bilateral eyes group(27 cases). All patients received single intravitreal injection of ranibizumab. The se-rum levels of GAS6,SDF-1 and VEGF were detected before treatment and 1,4 and 8 weeks after treatment. The visual acuity of patients were detected before treatment and 1 week after treatment. RESULTS:1,4 and 8 weeks after treatment,the serum levels of GAS6,SDF-1 and VEGF in 2 groups were decreased significantly,with statistical significance(P<0.05);but there was no sta-tistical significance between 2 groups(P>0.05). 1 week after treatment,the number of letter which had been seen by patient’s BC-VA were increased,compared to before treatment,with statistical significance(P<0.05);but there was no statistical significance between 2 groups(P>0.05). CONCLUSIONS:Intravitreal injection of ranibizumab can improve visual acuity of patients with pro-liferative diabetic retinopathy.
