Protective Effect of L-Ornithine-L-Aspartate on Ischemia-reperfusion Injury after Partial Hepatectomy
10.6039/j.issn.1001-0408.2015.26.38
- VernacularTitle:门冬氨酸鸟氨酸对肝部分切除术后缺血再灌注损伤的保护作用
- Author:
Xianchun LIANG
;
Wei WANG
;
Jun XIE
;
Li ZENG
- Publication Type:Journal Article
- Keywords:
L-ornithine-L-aspartate;
Partial hepatectomy;
Ischemia-reperfusion injury;
Liver function;
Protective effect
- From:
China Pharmacy
2015;(26):3717-3719
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the protective effect of L-ornithine-L-aspartate on ischemia-reperfusion injury after partial hepatectomy. METHODS:104 patients underwent partial hepatectomy(vessel occlusion in portal fissure)were randomly divided in-to control group(53 cases)and trial group(51 cases). Control group was given routine liver-protective drugs,and trial group was additionally given L-ornithine-L-aspartate 10 g added into 5%Glucose injection 250 ml intravenously before surgery,for 7 consecu-tive days. The fasting peripheral venous blood was collected in 2 groups on first day before surgery and first,forth and sixth day af-ter surgery to detect liver function;the changes of main aminopherase index(ALT and AST)were compared between 2 groups at different portal fissure vessel occlusion time after surgery. RESULTS:There was no statistical significance in the difference of liver resection range,blood loss,first porta hepatis vessel occlusion time and anesthesia time in both groups during operation (P>0.05). Compared to before surgery,liver function indexes raised to different extent in 2 groups after surgery,with statistical signifi-cance(P<0.05). The levels of AST and ALT in trial group were significantly lower than in control group on first,forth and sixth day after surgery,while albumin level was significantly higher than control group,with statistical significance(P<0.05). Total bili-rubin levels of both groups were approximate basically,there was no statistical significance(P>0.05). Among those patients under-went porta hepatis vessel occlusion with Pringle method and with occlude occlusion time ≥15 min,the AST and ALT level of con-trol group was higher than those of trial group after surgery,but albumin level was below trial group,with statistical significance (P<0.05). CONCLUSIONS:L-ornithine-L-aspartate could improve liver function fast and effectively for partial hepatectomy pa-tients,especially for the patients underwent porta hepatic vessel occlusion with Pringle method for a long time(obvious ischemia-re-perfusion injury).
