Efficacy Observation and Pharmacokinetic Study of Dexmedetomidine Combined with Propofol for Sepsis In-fection Deliration in Patients Underwent Continuous Intravenous Blood Replacement
10.6039/j.issn.1001-0408.2015.35.16
- VernacularTitle:右美托咪啶联合丙泊酚治疗连续静脉血液置换患者脓毒症感染谵妄的效果观察及药动学研究
- Author:
Genqu LI
;
Dong LI
;
Xuejun GUO
- Publication Type:Journal Article
- Keywords:
Sepsis;
Deliration;
Dexmedetomidine;
Propofol;
Drug combination;
Continuous intravenous blood replacement
- From:
China Pharmacy
2015;26(35):4946-4948
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe therapeutic efficacy of dexmedetomidine combined with propofol for sepsis infection deliration in patients underwent continuous intravenous blood replacement,and to study pharmacokinetic study. METHODS:60 patients with sepsis infection deliration underwent continuous intravenous blood replacement were selected and randomly divided into observation group and control group with 30 cases in each group. Control group was given propofol 0.5 mg/kg,and observa-tion group given dexmedetomidine and propofol. Therapeutic efficacy of 2 groups were analyzed comparatively,and pharmacoki-netic parameters of propofol were studied. RESULTS:The pharmacokinetic parameters of propofol as elimination half-life period (t1/2β),slow distribution half-life period (t1/2α) were shorter than literature reference value,with statistical significance (P<0.05),while the distribution rate constants(K21,K13,K10),the central compartment volume of distribution(VC),systemic clear-ance(CL),rapid distribution half-life period(t1/2pi)had no statistical significance,compared with literature reference value(P>0.05). After treatment,ICDSC score of 2 groups were decreased significantly,with statistical significance(P<0.05),while the observation group was significantly higher than the control group,with no statistical significance before and after treatment(P>0.05);the average hospital stay of observation group was significantly shorter than that of control group,with statistical signifi-cance(χ2=6.263 4,P=0.000);the incidence of ADR in control group was significantly higher than the observation group,with statistical significance(P<0.05). CONCLUSIONS:Dexmedetomidine combined with propofol have good effect on sepsis infec-tion deliration in patients underwent continuous intravenous blood replacement,and can reduce the length of hospital stay and the incidence of ADR.
