Progress in integrin in acute leukemia
10.3760/cma.j.issn.1009-9921.2016.08.017
- VernacularTitle:整合素在急性白血病中的研究进展
- Author:
Xiaoqing ZHU
- Publication Type:Journal Article
- Keywords:
Leukemia,acute;
Tumor microenvironment;
Integrins
- From:
Journal of Leukemia & Lymphoma
2016;25(8):506-508
- CountryChina
- Language:Chinese
-
Abstract:
Acute leukemia (AL) is an early hematopoietic stem/progenitor cell malignant cloning disease.Minimal residual disease and drug resistance are considered to be the origin of relapse and refractory.Recently,more and more evidences have shown that the interaction between leukemia cells and stromal cells or extracellular matrix in the bone marrow microenvironment can promote their survival,and enhance the resistance to conventional chemotherapy drugs.Integrin is the major molecule mediating the adhesion between leukemia cells and extracellular matrix (cellular and non cellular components),which plays a key role in cell proliferation,survival and other biological processes;however,the mechanism is not fully understood yet.This paper will review molecular mechanisms of the relationship between integrin and AL discovered recently.
