Progress in tumor suppressor gene PTEN in malignant tumors

VernacularTitle:抑癌基因PTEN在恶性肿瘤中的研究进展
Author: Na LI ; Tian TIAN
Publication Type:Journal Article
Keywords: Neoplasms; Tumor suppressor gene; PTEN
From: Cancer Research and Clinic 2016;28(8):568-573
CountryChina
Language:Chinese
Abstract: PTEN gene is considered to be the first discovered tumor suppressor gene with dual specificity phosphatase activity.The research has shown that the increasing popularity of PTEN rests on its important roles in cancer cell growth,differentiation,signaling transduction and cell apoptosis.Besides,the mutation of PTEN is related to cancer initiation and progression.The recent advances on PTEN gene in malignant tumors will be reviewed in this paper.