Effects of acupuncture on the expression of P2X receptors in the hippocampus of mice with a telomerase gene knocked out
10.3760/cma.j.issn.0254-1424.2016.08.003
- VernacularTitle:针刺足三里穴对端粒酶基因敲除小鼠海马P2X受体及其表达的影响
- Author:
Lili LIN
;
Qiang WU
;
Lidian CHEN
- Publication Type:Journal Article
- Keywords:
Acupuncture;
Electro-acupuncture;
Telomerase knockout;
P2X
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2016;38(8):572-575
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of P2X receptors in the hippocampus of telomerase gene knockout mice after acupuncturing the bilateral ST36 acupoints.Methods Eighteen telomerase gene knockout homozygous mice were randomly divided into a blank control group (group A),a manual acupuncture group (group B) and an electric acupuncture group (group C),each of 6.Group A was not given any intervention,while groups B and C were provided with manual or electric acupuncture at point ST36 for 7 days.The expression of P2X receptors and cAMP response element bound protein (CREB) in the hippocampus were observed and compared among the 3 groups.Results The expression of P2X4 in the hippocampus was not significantly different among the 3 groups in groups B and C decreased significantly compared with group A,but there were no significant differences between group Bs and C.The expression of CREB in group C decreased significantly compared with groups A and B.Conclusion EA inhibits the expression of P2X4 receptor and CREB the hippocampus.The signaling pathway may play an important role in the mechanism of action of acupuncture in neurodegenerative diseases.
