Relationship between single nucleotide polymorphisms of UGT1A6 and aspirin low responsiveness in patients with ischemic stroke
10.3760/cma.j.issn.1006-7876.2016.10.007
- VernacularTitle:UGT1A6单核苷酸多态性与缺血性卒中患者阿司匹林低反应性的关联性研究
- Author:
Keting LIU
;
Shuyu ZHOU
;
Biyang CAI
;
Qinqin CAO
;
Xinfeng LIU
- Publication Type:Journal Article
- Keywords:
Ischemic stroke;
Aspirin low responsiveness;
Uridine diphosphate glucuronosyltransferases enzymes
- From:
Chinese Journal of Neurology
2016;49(10):775-779
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between single nucleotide polymorphisms (SNPs) of UGT1 A6 and aspirin response in a cohort of Chinese Han population.Methods A total of 323 ischemic stroke patients consecutively registered in Nanjing Stroke Registry Program from September 2011 to October 2014 were enrolled.Three SNPs (rs6759892,rs2070959 and rs1105879) of UGT1A6 were genotyped in these ischemic stroke patients.Association of genotypes and aspirin response was evaluated by generalized linear model.Indicated with the inhibition rate of platelets,aspirin response was assessed by thromboelastograph.Results The mutation allele (G) of rs2070959 was positively related to platelets inhibition (β =0.084,P =0.010,Pcorrected =0.029),especially in male (β =0.098,P =0.006,Pcorrected =O.019).The dominant models of rs6759892,rs1105879 were also modestly related to aspirin response (P=0.015,Pcorrected=0.046 in both SNPs) in male.Thus the polymorphisms of UGT1A6 showed a relationship with aspirin response,especially in males.Conclusions The results indicated that genetic polymorphism of UGT1A6 might have an effect on individuals' aspirin response,especially in males.These findings can help clinicians to optimize the antiplatelet therapy for ischemic stroke patients.
