A retrospective case-control study of immunoglobulin G4-related disease combined with malignancy

VernacularTitle:IgG4相关性疾病合并恶性肿瘤的病例对照研究
Author: Yunlu FENG ; Dong WU ; Shengyu ZHANG ; Xi WU ; Huijun SHU ; Aiming YANG ; Jiaming QIAN
Publication Type:Journal Article
Keywords: IgG4-related disease; Malignancy; Diagnosis; Risk factors
From: Chinese Journal of Internal Medicine 2016;55(11):869-871
CountryChina
Language:Chinese
Abstract: IgG4-related disease (IgG4-RD) has been proved to be associated with malignancy.The incidence and risk factors of malignancy development in IgG4-RD were not clear.Nine IgG4-RD patients with malignancies and 27 IgG4-RD control cases were analyzed for risk factors and clinical features.The incidence of malignancy in IgG4-RD was 3.3％,higher than age-controlled general population.Smoking history was significantly more common in patients with malignancies than in the control group (9/9 vs 16/27,P ＜ 0.05).A total of 6/9 malignancies occurred within the first year after the diagnosis of IgG4-RD.Colorectal,biliary and thyroid cancers were the leading types.Smoking history is a risk factor for IgG4-RD associated malignancy.Careful vigilance to monitor malignancy needs to be paid during follow-up.