Progress in acute lymphoblastic leukemia cell lines
10.3760/cma.j.issn.1009-9921.2016.08.016
- VernacularTitle:人急性淋巴细胞白血病细胞系的研究进展
- Author:
Qian WANG
- Publication Type:Journal Article
- Keywords:
Leukemia,lymphoid,acute;
Cell lines;
Philadelphia chromosome;
Gene,MLL
- From:
Journal of Leukemia & Lymphoma
2016;25(8):501-505
- CountryChina
- Language:Chinese
-
Abstract:
Acute lymphoblastic leukemia (ALL) is a malignant clonal disease deriving from B or T lineage lymphoid precursors.ALL characterized by its high malignancy,poor curative effect and low remission rate occurs most frequently in pediatrics,but also accounts for 20 ％ of leukemia in adult.The further study of the biological feature and pharmacology may play a significant role in the improvement of the survival rate and life quality for ALL patients.The advent of continuous human ALL cell lines provides irreplacable cell-model for the occurrence,evolvement mechanism and drugs research in ALL.Besides,ALL cell lines established at present have covered most of the immunophenotyping and specificity chromosome abnormality,which promote the progress of genetics diagnosis and target therapy.This paper will review the advances in ALL cell lines,especially the cell lines with Ph chromosome and MLL gene alterations.
