Role of hypoxia inducible factor-1 in the development of acute pancreatitis
10.3760/cma.j.issn.1007-8118.2016.10.019
- VernacularTitle:缺氧诱导因子-1在急性胰腺炎发生发展中的作用
- Author:
Chengliang CAO
;
Fengzhi QU
;
Gang WANG
;
Bei SUN
- Publication Type:Journal Article
- Keywords:
Acute pancreatitis;
Hypoxia inducible factor-1;
Necrosis;
Apoptosis;
Triphosadenine
- From:
Chinese Journal of Hepatobiliary Surgery
2016;22(10):718-720
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic acinar cell death modality is a significant factor which determines the course and prognosis of acute pancreatitis (AP).The severity of AP is positively correlated with acinar necrosis,while negatively correlated with acinar apoptosis.Adenosine triphosphate (ATP) level is the key to control the manner of death,and acts as a switch during the conversion of necrosis and apoptosis in a variety of pathophysiological settings:low levels of ATP can accelerate cell necrosis and high levels of ATP might promote apoptosis.Hypoxia inducible factor 1 (HIF-1) is a highly expressed transcription factor in anoxic conditions which can effectively regulate cell energy metabolism and play an important role in regulating cell death and inflammatory injury.Therefore,this review aimed to provide a reference about better understanding of the pathogenesis and new therapeutic targets of HIF-1 in AP.
