Establishment of dual liver transplantation rat model

VernacularTitle:大鼠双肝移植模型的建立
Author: Hao CHEN ; Tianliang SONG ; Zhijian HAN ; Aiqun ZHANG ; Xiaohong LIU ; Zhengkui PENG ; Yumin LI
Publication Type:Journal Article
Keywords: Dual liver transplantation; Animal model; Rat
From: Chinese Journal of Hepatobiliary Surgery 2016;22(9):630-632
CountryChina
Language:Chinese
Abstract: Objective To establish a dual liver transplantation rat model,which could benefit the future clinical practice.Methods Y type vein derived from the crossover segment of vena cava and two iliac veins in donor and Y type bile duct prosthesis were employed to recanalize portal vein and bile duct from dual liver grafts to recipient liver.The dual right upper lobes with about 45％～ 50％ of the recipient liver volume were taken as donor.One was orthotopically implanted at its original position,while the other was rotated 180° sagittally and heterotopically positioned in the left upper quadrant.Survival rate was analyzed to evaluate the function of dual liver grafts.Results A total of 7 rats which underwent dual liver transplantation survived more than 7 days and the survival rate was 58.3％.5 rats died due to abdominal hemorrhage,bile leakage and liver abscess.Conclusion Using Y type vein and bile duct prosthesis,we successfully established a novel rat model of dual right upper liver lobe transplantation.