Research advances in prevention and treatment of cerebral radiation necrosis

VernacularTitle:放射性脑坏死的新认识与防治
Author: Xiaoshen WANG ; Chaosu HU
Publication Type:Journal Article
Keywords: Radiation cerebral necrosis; New knowledge; Prevention and cure
From: Chinese Journal of Radiation Oncology 2016;25(9):911-916
CountryChina
Language:Chinese
Abstract: Cerebral radiation necrosis (CRN) is a serious complication of radiotherapy for intracranial tumors and skull base tumors.Since there lacked effective therapeutic methods in the past,CRN was once considered to be progressive and irreversible.With the development of histopathology and neuroimaging,the development and progression of CRN is gradually clarified,and new therapeutic methods have been developed.In recent years,the scholars at home and abroad have tried to use bevacizumab (a humanized monoclonal antibody targeting vascular endothelial growth factor),nerve growth factor,and ganglioside in the treatment of CRN and have achieved definite therapeutic effects.In some patients,cerebral necrosis was even repaired and reversed.This article reviews the incidence,pathophysiology,treatment,and prognosis of CRN.