Research status of hippocampal dysfunctions caused by cranial irradiation
10.3760/cma.j.issn.0254-5098.2016.09.017
- VernacularTitle:放射性海马功能障碍的研究现状
- Author:
Xin DING
;
Ye TIAN
- Publication Type:Journal Article
- Keywords:
Cranial radiation;
Hippocampal dysfunction;
Neurogenesis
- From:
Chinese Journal of Radiological Medicine and Protection
2016;36(9):712-716
- CountryChina
- Language:Chinese
-
Abstract:
Cranial irradiation is routinely used for the treatment of almost all brain tumors,but it may cause disastrous injury in brain,especially in the hippocampus that has cognitional and emotional regulation functions.Several studies have investigated the mechanisms of radiation-induced hippocampal dysfunctions such as hippocampal neurogenesis,neurotrophin and neuroinflammation,and provided effective prevention strategies such as exercise,environmental enrichment,anti-inflammatory and intrahippocampal transplantation of neural stem cells.This review discussed the curent progresses and challenges of hippocampal dysfunction induced by cranial irradiation and provided new insights for preclinical and clinical researches.
