Application of active breathing control (ABC) and four dimensional CT technology in stereotactic radiotherapy of lung tumor
10.3760/cma.j.issn.0254-5098.2016.09.006
- VernacularTitle:主动呼吸控制和四维CT技术在肺部肿瘤立体定向放射治疗中的应用
- Author:
Lu YANG
;
Yingjie ZHANG
;
Guangjun LI
;
Dajiang WANG
;
Fubo LIU
;
Sen BAI
- Publication Type:Journal Article
- Keywords:
Active breathing control;
4D-CT;
Stereotactic body radiation therapy;
Prescription dose;
Lung tumor
- From:
Chinese Journal of Radiological Medicine and Protection
2016;36(9):667-671
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the difference of lung and target volume and dosimetry characteristics features of deep inhalation breathing holding-active breathing control (ABC) and the four dimensional CT (4D-CT) free breathing in stereotactic body radiation therapy (SBRT) technology for patients with lung cancer.Methods 10 patients with pulmonary malignant tumor who were proposed SBRT treatment were selected,and received CT under free breath (FB-CT),4D-CT scan under quiet respiration (4D-CT) and active breathing control CT scan (ABC-CT),respectively.With SBRT technology under the same condition designed four corresponding plans,FB-CT,ABC-CT,4D-CT and 4D-CT0 which was the end inspiratory phase of 4D-CT respectively.The lung volume(V),PTV,V5,V20,mean lung dose(MLD) and normal tissue complication probability(NTCP) of four treatment programs were counted and compared.Results Compared with FB-CT,V,PTV,V5,V20,MLD and NTCP of ABC-CT were 51.48％,-65.34％,-42.64％,-56.62％,-40.22％ and-98.53％ (t=-7.14 to6.16,P＜0.05);PTV,V5,V20,MLD and NTCP of 4D-CT were-40.14％,-16.90％,-37.16％,-17.85％ and-90.96％ (t =0.54 to 3.22,P＜0.05);PTV,V5,V20,MLD and NTCP of 4D-CT0 were-68.98％,-30.21％,-48.49％,-37.45％ and-95.82％ (t=1.32 to 5.46,P＜0.05),respectively.Compared with FB-CT,the lung volume of 4D-CT and 4D-CT0 had no statistical difference (P ＞ 0.05).Conclusions ABC-CT methods have ideal clinical characteristics,with larger double lung volume,smaller artifacts of image,and higher target matching precision.ABC-CT methods reduce the dose of normal lung tissues significantly.
