Influence of chromatin structure on the radiation sensitivity of tumor cells
10.3760/cma.j.issn.0254-5098.2016.09.018
- VernacularTitle:染色质结构影响肿瘤细胞辐射敏感性的研究进展
- Author:
Ping WANG
;
Dexiao YUAN
;
Chunlin SHAO
- Publication Type:Journal Article
- Keywords:
Chromatin structure;
Radiation sensitivity;
Histone modification;
Chromatin remodeling;
DNA repair.
- From:
Chinese Journal of Radiological Medicine and Protection
2016;36(9):717-720
- CountryChina
- Language:Chinese
-
Abstract:
Cumulative evidence demonstrated that the chromatin modification plays important roles in the processes of DNA replication,transcription,repair and recombination.Both of the generation of DNA lesions and the activation of DNA damage response (DDR) to ionizing radiation could be affected by the chromatin modifications.This paper reviewed the recent research progresses in the chromatin structure modifications and its role in DDR,especially the influence of characteristic chromatin structure and histone modification on the radiation sensitivity of tumor cells.
