Expression of glucose transporters in the developing rat skin.
10.5115/acb.2017.50.3.214
- Author:
Chang Seok OH
1
;
Jong Ha HONG
;
Shun Nu JIN
;
Wang Jae LEE
;
Young Soo LEE
;
Eunju LEE
Author Information
1. Department of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Glucose transporter;
Skin;
Epidermis;
Rat;
Immunohistochemistry
- MeSH:
Amniotic Fluid;
Animals;
Epidermis;
Female;
Glucose Transport Proteins, Facilitative;
Glucose*;
Immunohistochemistry;
Pregnancy;
Rats*;
Skin*
- From:Anatomy & Cell Biology
2017;50(3):214-218
- CountryRepublic of Korea
- Language:English
-
Abstract:
We found the changed distribution of glucose transporter (GLUT) proteins in the skin during rat development. At 15 days of gestation, GLUT1 and 2 proteins were expressed in the stratum corneum of epidermal cells. In postnatal skin, however, GLUT1 and 2 exhibit different expression patterns. While GLUT1 expression becomes more restricted to the stratum basale with development, GLUT2 was found mainly in stratum spinosum and granulosum, but not being localized in the stratum basale at any stages of perinatal skin development. Considering all these, it can be speculated that each GLUT protein plays its specific role in different epidermal layers and that the glucose used in mammalian skin in utero could be originated from the amniotic fluid during skin development.
