Diagnosis and management of recurrent or resistant gestational trophoblastic neoplasia
10.3760/cma.j.issn.1008-1372.2016.09.051
- VernacularTitle:耐药性复发性妊娠滋养细胞肿瘤的诊治策略
- Author:
Binzhou SUN
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
Gestational trophoblastic neoplasms/DI/TH;
Drug tolerance;
Recurrence;
Review
- From:
Journal of Chinese Physician
2016;18(9):1438-1440
- CountryChina
- Language:Chinese
-
Abstract:
With the application of chemotherapy,gestational trophoblastic neoplasia (GTN) has been the first of malignant tumors which can be cured by chemotherapy.However,the resistance and relapse still is the difficulty of treatment and the leading cause of death in patients.Approximately 20％ ～ 30％ of GTN tumor will be resistant to,or will relapse after cure.These resistant and relapsed lesions will require salvage therapy,which be treated with multi-agent chemotherapy with or without surgery and/or adjuvant radiation therapy.Various salvage regimens are used worldwide.It is unclear to determine which of the various salvage combinations,if any,was the most effect and the least toxic for the treatment of resistant or relapsed GTN.
