Epstein-Barr virus and inflammatory bowel disease
10.3760/cma.j.issn.1008-1372.2016.09.001
- VernacularTitle:EB病毒与炎症性肠病
- Author:
Lu XIA
;
Xiaoping WU
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel diseases;
Herpesvirus 4,human
- From:
Journal of Chinese Physician
2016;18(9):1281-1284
- CountryChina
- Language:Chinese
-
Abstract:
Epstein-Barr Virus (EBV) is the first human virus related to oncogenesis.EBV infection is associated with inflammatory bowel disease (IBD) with unknown causality.The prevalence of EBV in intestinal tissue from patients with IBD is significantly higher and related to the exacerbation of the disease and refractory IBD.Immunosuppressive therapy has improved outcomes associated with IBD.However,it is also associated with an increased risk of opportunistic infection,and lymphoproliferative disorders (LDs) maybe due to EBV infection.Here we review our current understanding of the pathogenesis of EBV infection in colonic mucosal inflammation,EBV-induced disease exacerbation,lymphomagenesis in IBD,and clinical approaches therefrom.
