The factors affecting the survival and prognosis of patients with Ⅲ ～ Ⅳ gastric cancer: a report of 156 cases
10.3760/cma.j.issn.1008-1372.2016.08.016
- VernacularTitle:影响Ⅲ～Ⅳ期胃癌患者生存及预后因素:附156例报道
- Author:
Qiang RUAN
;
Shuzhong CUI
;
Xiangliang ZHANG
;
Yinbing WU
;
Hongsheng TANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Prognosis
- From:
Journal of Chinese Physician
2016;18(8):1185-1189
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the factors affecting the survival and prognosis of patients with stage Ⅲ～ Ⅳgastric cancers.Methods A total of 156 cases of Ⅲ ～ Ⅳ gastric cancer was studied retrospectively from September 1,2006 to December 31,2012.Kaplan-Meier analysis,Log-rank univariate analysis,Cox proportional hazards model analysis were used to analyze survival and prognostic factors.Results Twelve cases were lost,to the end of the follow-up,22 cases were alive.The median survival time was 29.3 months.1-year,3-year,and 5-year overall survival rates were 83.3％,37.8％,and 21.2％,respectively.Univariate analysis showed that tumor size,tumor node metastasis (TNM) staging,curative resection,hyperthermic intraperitoneal perfusion chemotherapy (HIPEC),and postoperative chemotherapy were correlated with prognosis (P ＜0.05 for all).Multivariate analysis showed that TNM staging,curative resection,HIPEC,and postoperative chemotherapy were independent prognostic factors (P ＜ 0.01 for all).Conclusions TNM staging,curative resection,hyperthermic intraperitoneal perfusion chemotherapy and postoperative chemotherapy are the independent factors affecting the prognosis of stage Ⅲ～ Ⅳ gastric cancer after resection.Hyperthermic intraperitoneal perfusion chemotherapy and postoperative chemotherapy can improve their survival.
