Proton pump inhibitors and the pathophysiological mechanism of the risk of gastric cancer and its clinical researchs progress
10.3760/cma.j.issn.1008-1372.2016.08.045
- VernacularTitle:质子泵抑制剂与胃癌风险性病理生理机制及临床研究进展
- Author:
Guoliang ZHANG
;
Yuanshui SUN
- Publication Type:Journal Article
- Keywords:
Proton pump inhibitors/AE;
Stomach neoplasms/PP/ET;
Review
- From:
Journal of Chinese Physician
2016;18(8):1268-1271
- CountryChina
- Language:Chinese
-
Abstract:
Proton pump inhibitors as a kind of acid drug are widely used in clinical.However,it is overused all over the world although generally safe and effective.Studies have shown the uncertainty of potential long-term adverse effects,especially the contact with the mechanism of gastric cancer.Clinicians should pay more attention to the potential carcinogenic risk of long-term proton pump inhibitors in treatment.The mechanism of pathophysiology and the clinical researches of proton pump inhibitor-induced gastric neuroendocrine tumors,gastric carcinoma,and gastric cardia cancers are summarized as follows.