Proton pump inhibitors and the pathophysiological mechanism of the risk of gastric cancer and its clinical researchs progress

VernacularTitle:质子泵抑制剂与胃癌风险性病理生理机制及临床研究进展
Author: Guoliang ZHANG ; Yuanshui SUN
Publication Type:Journal Article
Keywords: Proton pump inhibitors/AE; Stomach neoplasms/PP/ET; Review
From: Journal of Chinese Physician 2016;18(8):1268-1271
CountryChina
Language:Chinese
Abstract: Proton pump inhibitors as a kind of acid drug are widely used in clinical.However,it is overused all over the world although generally safe and effective.Studies have shown the uncertainty of potential long-term adverse effects,especially the contact with the mechanism of gastric cancer.Clinicians should pay more attention to the potential carcinogenic risk of long-term proton pump inhibitors in treatment.The mechanism of pathophysiology and the clinical researches of proton pump inhibitor-induced gastric neuroendocrine tumors,gastric carcinoma,and gastric cardia cancers are summarized as follows.