Progress of diagnosis and treatment in children with thrombotic microangiopathy
10.3760/cma.j.issn.2095-428X.2016.17.004
- VernacularTitle:儿童血栓性微血管病的诊断及治疗进展
- Author:
Xiaorong LIU
- Publication Type:Journal Article
- Keywords:
Thrombotic microangiopathy;
Hemolytic uremic syndrome;
Thrombotic thrombocytopenic purpura;
Diagnosis;
Treatment;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2016;31(17):1292-1295
- CountryChina
- Language:Chinese
-
Abstract:
Thrombotic microangiopathy is a group of clinical and pathological syndrome,characterized mainly by hemolytic anemia,thrombocytopenia,and multiple organ dysfunctions,caused by a variety of reasons.Classic types of thrombotic microangiopathy include hemolytic uremic syndrome,and thrombotic thrombocytopenic purpura.Hemolytic uremic syndrome is a critically ill glomerular disease,of which 90％ found in children.Depending on the pathogenesis,hemolytic uremic syndrome is currently divided into 2 categories,namely,typical and atypical hemolytic uremic syndromes.Atypical hemolytic uremic syndrome onsets rapidly,is dangerous disease,tends to recurring easily,and has high mortality in its acute phase.Nowadays,great interest is focused on the important role of the excessive activation of the alternative complement pathway in the pathogenesis of atypical hemolytic uremic syndrome.This article report the recent advances on the cause,diagnosis,and treatment of thrombotic microangiopathy.
