Progress in targeted nanoparticle for the therapy of liver fibrosis
10.3760/cma.j.issn.1673-4181.2016.04.008
- VernacularTitle:肝靶向纳米给药系统治疗肝纤维化的研究进展
- Author:
Jingwen ZHAO
- Publication Type:Journal Article
- Keywords:
Liver fibrosis;
Nanotechnology;
Targeted therapy
- From:
International Journal of Biomedical Engineering
2016;39(4):226-232
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is an important pathological hallmark in the early stage of chronic liver injury,which can be gradually treated by drug treatment.Traditional medicine has limited therapeutic effect and is toxic to the normal organs.The drug delivery system based on nanotechnology can overcome the deficiency of traditional drugs to protect the drug which can be delivered to the target cells.Four major types of cells in liver play critical role in liver fibrogenesis,including hepatocytes,hepatic stellate cells,kupffer cells and hepatic sinusoidal endothelial cells.Liver targeted nanomedicine can be delivered to these liver cells based on their material and functional modification and enhance anti-inflammatory and anti-fibrotic effect.They also can reduce the toxic side effects and reverse liver fibrosis.This article gives an overview on current strategies of the application of nanotechnology in targeting treatment for liver fibrosis.
