Postoperative adjuvant chemotherapy after neoadjuvant chemoradiation for advanced rectal carcinoma: a meta-analysis
10.3760/cma.j.issn.1007-631X.2016.10.020
- VernacularTitle:术后辅助化疗对新辅助放化疗后的进展期直肠癌患者预后影响的Meta分析
- Author:
Quanlin LI
;
Mingyang REN
;
Yueqin CHEN
;
Xiaocui HE
;
Na XU
;
Dan BO
;
Bin HUANG
- Publication Type:Journal Article
- Keywords:
Rectal neoplasms;
Chemoradiotherapy,adjuvant;
Prognosis
- From:
Chinese Journal of General Surgery
2016;31(10):863-867
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the impact of postoperative adjuvant chemotherapy on prognosis of patients with advanced rectal carcinoma using a meta-analysis.Methods We searched PubMed to identify literature comparing observation with adjuvant chemotherapy after neoadjuvant chemoradiotherapy and surgery for patients with advanced rectal carcinoma.Data were analysed using Revman 5.0 statistical software.Results Nine trials were included consisting of 6 212 patients:3 421 patients received adjuvant chemotherapy and 2 791 patients did not.The age ranged from 55.6 to 68 years.Adjuvant chemotherapysignificantly affects overall and disease-free survival (P =0.002 and P =0.000 5 respectively) of patientswho had received neoadjuvant chemoradiotherapy.The subgroup analysis which originate from insufficient data reveales ypT0-2 patients and ypT3-4 patients can't benefit from adjuvant chemotherapy.Conclusion Postoperative adjuvant chemotherapy can improve the survival of advanced rectal carcinoma patients after neoadjuvant chemoradiotherapy,but can't increase the survival of pathology complete respone and yPN + patients.
