Morphological features and surgical management of giant cell tumor of bone

VernacularTitle:骨巨细胞瘤的形态学特征及其治疗方法的选择
Author: Xianjia NING ; Dengxing LUN ; Yongcheng HU
Publication Type:Journal Article
From: Chinese Journal of Orthopaedics 2016;36(20):1335-1340
CountryChina
Language:Chinese
Abstract: Giant cell tumour of bone is one of the most common primary musculoskeletal tumours,accounting for 10％-21％ of bengin bone tumours,which can behave like malignant tumors and have benign histologic characteristics.Giant cell tumour (GCT) of bone is classified by the World Health Organisation (WHO) as a benign but locally aggressive tumour.Intralesional excision and wide resection may be helpful in operative treatment for GCT.However,there are limitations with these options in spite of the use of adjuvant therapy.For instance,intralesional excision had more local recurrence rate and less complications,wide resection had less local recurrence and poor functional results.Therefore,there is no widely held consensus regarding the ideal treatment selection for all GCT patients.The purpose is to review literature reports on the morphological features of GCT of bone and existing surgical method,and discuss the relationship between morphology characteristics of GCT and the selection of surgical options and postoperative recurrence rate,in order to help oncological doctors to choose surgical method in the clinical practice.