Study on pre-attentive change detection indexed by auditory MMN in undergraduate students with major depressive disorder

VernacularTitle:大学生抑郁症患者听觉信息前注意加工的失匹配负波研究
Author: Zhengxue QIAO ; Guodong SUN ; Xin CAI ; Xiaohui QIU ; Xiuxian YANG ; Yanjie YANG
Publication Type:Journal Article
Keywords: Major depressive disorder; Undergraduate students; Pre-attentive processing; Mismatch negativity
From: Chinese Journal of Behavioral Medicine and Brain Science 2016;25(9):803-806
CountryChina
Language:Chinese
Abstract: Objective To explore pre-attentive information processing in undergraduate students with major depressive disorder(MDD) indexed by auditory mismatch negativity (MMN) and provide scientific theory basis for the diagnosis of MDD.Methods In the deviant-standard reverse oddball paradigm with deviant stimulus presentation probability of 20％,duration auditory MMN was obtained in 17 MDD university students and 17 gender-/age-matched healthy undergraduate students.All data were analyzed by statistics means of repeated measurement of F test.Results The amplitudes of 150 ms MMN over the frontal-central area were smaller in MDD undergraduate students((-0.34± 1.24) μV) than those in healthy undergraduate students ((-1.07± 1.55) μV,F=24.318,P=0.000).The 50 ms MMN did not differ between MDD students ((-1.96± 1.14) μV) and healthy undergraduate students ((-1.23 ± 1.97) μV,F =0.089,P =0.767).Conclusion Pre-attentive auditory information processing is impaired in MDD undergraduate students.