The 5-HTT gene polymorphisms correlated with the clinical manifestations of depression

Wenjiao Min; Bo Zhou; Min MA; Yunge LI; Chuanxin Liu; Bo Zhang; Xueli Sun

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The 5-HTT gene polymorphisms correlated with the clinical manifestations of depression

VernacularTitle:5-羟色胺转运蛋白基因多态性与抑郁症临床表型的关联性
Author: Wenjiao MIN ; Bo ZHOU ; Min MA ; Yunge LI ; Chuanxin LIU ; Bo ZHANG ; Xueli SUN
Publication Type:Journal Article
Keywords: 5-HTT; Gen polymorphism; Depression
From: Chinese Journal of Behavioral Medicine and Brain Science 2016;25(9):797-802
CountryChina
Language:Chinese
Abstract: Objective To determine the potential correlation of 5-HTT gene polymorphisms (5-HTTLPR and STin2) with clinical manifestations in depression.Methods A total of 401 depressed patients,all of Chinese Han region,were collected and genotyped by polymerase chain reactions (PCR).All patients were evaluated using a 17-item Hamilton depression rating scale (HAMD-17) and Hamilton anxiety rating scale (HAMA),and then associated analysis was applied.Results (1) The age of onset in patients with L/S genotype of 5-HTLPR polymorphism were much younger than that of patients with L/L and S/S genotype (F=3.281,P=0.039).Besides,there was also a significant difference of HAMA1 (anxious mood) scores among patients with different genotypes for 5-HTTLPR polymorphism,where the scores of those with L/S genotype were the highest (2.34±0.80,P=0.010).(2) The scores of HAMD10 (mental anxiety),HAMA1 (anxious mood),HAMA3 (fear) and mental anxiety factor were higher in patients with 12/10 genotype than patients with 12/12 and 10/10 genotype for STin2 polymorphism (2.40±0.83,2.38±0.90,1.42± 1.04,14.60±4.26 respectively;P value:0.014,0.044,0.03 and 0.006 respectively).The scores of HAMD10(mental anxiety) and mental anxiety factor were (2.11±0.77),(12.96±3.78) in the 12/12 genotype patients,and significantly lower than that in the 12/10 genotype patients (adjustedPvalue:0.018,0.006).Conclusions A positive association of the 5-HTT polymorphisms with anxious symptoms in depressed patients is revealed.These findings might provide some evidences for the clinical phenotype and optimization of depression treatment.