New progress of pathogenesis in ventilator-induced lung injury

VernacularTitle:呼吸机相关性肺损伤发病机制研究新进展
Author: Yiyi YANG ; Shanglong YAO ; You SHANG
Publication Type:Journal Article
Keywords: Acute respiratory distress syndrome; Ventilator-induced lung injury; Biotrauma; Epithelial-mesenchymal transition
From: Chinese Critical Care Medicine 2016;28(9):861-864
CountryChina
Language:Chinese
Abstract: Mechanical ventilation is not only an important treatment method of acute respiratory distress syndrome (ARDS),but also one of the basic treatments in the intensive care unit (ICU).However,mechanical ventilation itself can cause or aggravate acute lung injury,which is called ventilator-induced lung injury (VILI).Currently,clinical pathogenesis of VILI includes four categories such as barotrauma,volutrauma,atelectrauma and hiotrauma.The pathogenesis of mechanical injury has been widely accepted,but the biological injury pathogenesis is unclear.With further research,we found that in the late stage VILI patients occured proliferation of puhnonary fibrosis,which may be formed by partial epithelial-mesenchymal transdifferentiation (EMT).Further study of specific pathogenesis of biotrauma and ARDS pulmonary fibrosis proliferation could provide new ideas for the clinical treatment of VILI.