Effects of programmed death 1 and its ligand in primary hepatic carcinoma
10.3760/cma.j.issn.1673-9752.2016.10.017
- VernacularTitle:程序性死亡因子1及其配体在原发性肝癌中的作用
- Author:
Min DENG
;
Jun CHEN
;
Yudong QIU
- Publication Type:Journal Article
- Keywords:
Programmed death 1;
Programmed death ligand 1;
Liver neoplasms;
Immune escape;
Immunotherapy
- From:
Chinese Journal of Digestive Surgery
2016;15(10):1029-1032
- CountryChina
- Language:Chinese
-
Abstract:
Cancer cells can secrete programmed death ligand 1 (PD-L1) to bind with inhibitory regulatory protein of programmed death 1 (PD-1) which lies on T-cell lymphocyte.Consequently,the activity of the T cells reduces,and the apoptosis cells increase.It's one of the pathways of newly discovered tumor immune escape.Primary hepatic cancer is one of the common malignant tumors of digestive system and closely related to viral hepatitis B in China.PD-1/PD-L1 pathway plays an important role in tumorigenesis and development of primary liver cancer.In this paper,the research updates of PD-1/PD-L1 in primary hepatic carcinoma were summarized.
