Mechanism of epithelial-mesenchymal transition in the invasion and metastasis of colorectal cancer
10.3760/cma.j.issn.1673-4203.2016.05.018
- VernacularTitle:上皮间质转化在结直肠癌侵袭转移中的作用机制
- Author:
Weiqiang YOU
;
Nengquan SHENG
;
Zhigang WANG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Neoplasm invasiveness;
Neoplasms;
Metastasis;
Epithelial-mesenchymal transition;
Mechanism
- From:
International Journal of Surgery
2016;43(5):349-352
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial-mesenchymal transition is the phenomenon of epithelial cells transforming to mesenchymal cells under special microenvironment,and thus tumor cells obtain characters such as difficult to adhere,motility enhancement,resistant to apoptosis.In the process of embryonic growth and tumor development,epithelial cells were found to be transformed into mesenchymal cells.Many researches showed that epithelial-mesenchymal transition plays an important role during the invasion and metastasis of colorectal cancer,and its mechanism involves many kinds of signaling pathways and related molecules.
